ISOLATION OF THE ACTIVATOR (A) OF BILIRUBIN GLUCURONYL TRANSFERASE (BGt) ROM NORMAL (JJ) AND HOMOZYGOUS (jj) GUNN RATS
نویسندگان
چکیده
منابع مشابه
The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin.
The role of high serum and tissue levels of unconjegated bilirubin in the pathogenesis of the impaired urinary concentrating ability was investigated in homozygous (jj) Gunn rats with the congenital absence of hepatic glucuronyl transferase. Continuous phototherapy with blue fluorescent lights at a wave length of 460 nm or oral cholestyramine feeding or both reduced serum levels of unconjugated...
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متن کاملUrobilinogen-i is a major derivative of bilirubin in bile of homozygous Gunn rats.
Gunn rats lack bilirubin UDP-glycosyltransferases, but diazo-negative derivatives of bilirubin have been described in their bile. In order to investigate this alternative disposal of bilirubin, crude bile samples from Gunn and Wistar rats were directly analysed by h.p.l.c. Besides bilirubin (in Gunn rats) or its glycosides (in Wistar rats), two major compounds were detected. A yellow one corres...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1987
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198704010-00639